Implication of Genetic Variants Near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in Type 2 Diabetes and Obesity in 6,719 Asians

• DOI: 10.2337/db07-1583
• Publication Date: 2008-05-10T01:21:31Z
• Authors: Maggie C.Y. Ng; Kyong Soo Park; Bermseok Oh; Claudia H.T. Tam; Young Min Cho; Hyoung Doo Shin; Vincent K.L. Lam; Ronald C.W. Ma; Wing Yee So; Yoon Shin Cho; Hyung-Lae Kim; Hong Kyu Lee; Juliana C.N. Chan; Nam H. Cho
• Keywords: TCF7L2; FTO gene

Recent genome-wide association studies have identified six novel genes for type 2 diabetes and obesity confirmed TCF7L2 as the major gene to date in Europeans. However, implications of these Asians are unclear.We studied 13 associated single nucleotide polymorphisms from 3,041 patients with 3,678 control subjects Asian ancestry Hong Kong Korea.We associations TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/CDKN2B, IGF2BP2, FTO risk diabetes, odds ratios ranging 1.13 1.35 (1.3 x 10(-12) < P(unadjusted) 0.016). In addition, A allele rs8050136 at was increased BMI (P(unadjusted) = 0.008). we did not observe significant any genetic variants surrogate measures insulin secretion or sensitivity indexes a subset 2,662 subjects. Compared carrying zero, one, two alleles, each additional 17% risk, there an up 3.3-fold those eight more alleles. Despite most effect sizes being similar between Europeans meta-analyses, ethnic differences frequencies lead variable attributable risks populations.Our findings support important but differential contribution compared