Changes in Insulin Sensitivity and Insulin Release in Relation to Glycemia and Glucose Tolerance in 6,414 Finnish Men

• DOI: 10.2337/db08-1607
• Publication Date: 2009-02-18T03:43:37Z
• Authors: Alena Stančáková; Martin Javorský; Teemu Kuulasmaa; Steven M. Haffner; Johanna Kuusisto; Markku Laakso
• Keywords: Impaired fasting glucose

OBJECTIVE We evaluated insulin sensitivity and secretion across the entire range of fasting (FPG) 2-h plasma glucose (PG), we investigated differences in release different tolerance categories. RESEARCH DESIGN AND METHODS A total 6,414 Finnish men (aged 57 ± 7 years, BMI 27.0 3.9 kg/m2) from our ongoing population-based METSIM (Metabolic Syndrome Men) study were included. Of these subjects, 2,168 had normal tolerance, 2,859 isolated impaired (IFG), 217 (IGT), 701 a combination IFG IGT, 469 newly diagnosed type 2 diabetes. RESULTS The Matsuda index decreased substantially within FPG (−17%) PG (−37%) was approximately −65 −53% diabetic PG, respectively, compared with reference (FPG <5.0 mmol/l). Early-phase declined by only −5% but significantly (by 32–70%) 33–51%). Changes relation to hyperglycemia independent obesity. predominant feature IGT peripheral sensitivity. Isolated characterized early release. CONCLUSIONS Peripheral already at low levels normoglycemic range, whereas impairment observed mainly PG. Obesity did not affect changes or hyperglycemia.