Physical Exercise Reduces Circulating Lipopolysaccharide and TLR4 Activation and Improves Insulin Signaling in Tissues of DIO Rats

• DOI: 10.2337/db09-1907
• Publication Date: 2011-02-01T03:22:55Z
• Authors: Alexandre G. Oliv...; Bruno M. Carvalho; Natália Tobar; Eduardo R. Ropelle; José R. Pauli; Renata A. Bagarolli; Dioze Guadagnini; José B.C. Carvalh...; Mario J.A. Saad
• Keywords: Lipopolysaccharides; Male; 2. Zero hunger; 0301 basic medicine; Analysis of Variance; Interleukin-6; Blotting, Western; JNK Mitogen-Activated Protein Kinases; Enzyme-Linked Immunosorbent Assay; Diet; I-kappa B Kinase; Mice; 03 medical and health sciences; Adipose Tissue; Liver; Physical Conditioning, Animal; Glucose Clamp Technique; Animals; Insulin; Obesity; Insulin Resistance; Phosphorylation; Muscle, Skeletal; Obesity Studies

Insulin resistance in diet-induced obesity (DIO) is associated with a chronic systemic low-grade inflammation, and Toll-like receptor 4 (TLR4) plays an important role the link among insulin resistance, obesity. The current study aimed to analyze effect of exercise on TLR4 expression activation obese rats its consequences sensitivity signaling.