Gliotransmission and Brain Glucose Sensing

• DOI: 10.2337/db11-0785
• Publication Date: 2012-11-17T06:37:53Z
• Authors: Damien Lanfray; Sébastien Arthaud; Johanne Ouellet; Vincent Compère; Jean-Luc Do Rego; Jérôme Leprince; Benjamin Lefranc; Hélène Castel; Cynthia Bouchard; Boris Monge-Roffa...; Denis Richard; Georges Pelletier; Hubert Vaudry; Marie-Christine T...; Fabrice Morin
• Keywords: Blood sugar regulation; Homeostasis

Hypothalamic glucose sensing is involved in the control of feeding behavior and peripheral homeostasis, glial cells are suggested to play an important role this process. Diazepam-binding inhibitor (DBI) its processing product octadecaneuropeptide (ODN), collectively named endozepines, secreted by astroglia, ODN a potent anorexigenic factor. Therefore, we investigated involvement endozepines brain sensing. First, showed that intracerebroventricular administration rats increases DBI expression hypothalamic glial-like tanycytes. We then demonstrated stimulates endozepine secretion from explants. Feeding experiments indicate effect central was blunted coinjection antagonist. Conversely, hyperphagic response elicited glucoprivation suppressed agonist. The effects centrally injected or agonist were blockade melanocortin-3/4 receptors, suggesting involves endozepinergic melanocortin pathway. Finally, found modulate blood levels, their feedback loop controlling whole-body homeostasis. Collectively, these data critical relay potentially new targets treatment metabolic disorders.