Consistent Directions of Effect for Established Type 2 Diabetes Risk Variants Across Populations

• DOI: 10.2337/db11-1296
• Publication Date: 2012-04-04T05:53:32Z
• Authors: Christopher A. Ha...; Megan D. Fesinmeyer; Kylee L. Spencer; Petra Bůžková; V. Saroja Voruganti; Peggy Wan; Jeff Haessler; Nora Franceschini; Kristine R. Monroe; Barbara V. Howard; Rebecca D. Jackson; Jose C. Florez; Laurence N. Kolonel; Steven Buyske; Robert J. Goodloe; Simin Liu; JoAnn E. Manson; James B. Meigs; Kevin Waters; Kenneth J. Mukamal; Sarah A. Pendergrass; Peter Shrader; Lynne R. Wilkens; Lucia A. Hindorff; Jose Luis Ambite; Kari E. North; Ulrike Peters; Dana C. Crawford; Loic Le Marchand; James S. Pankow
• Keywords: Genetic Association

Common genetic risk variants for type 2 diabetes (T2D) have primarily been identified in populations of European and Asian ancestry. We tested whether the direction association with 20 T2D generalizes across six major racial/ethnic groups U.S. as part Population Architecture using Genomics Epidemiology Consortium (16,235 case 46,122 control subjects American, African Hispanic, East Asian, American Indian, Native Hawaiian ancestry). The percentage positive (odds ratio [OR] >1 putative allele) associations ranged from 69% Indians to 100% Americans. Of nine where we observed significant heterogeneity effect by group (P(heterogeneity) < 0.05), eight were positively associated (OR >1) at least five groups. marked directional consistency most implies a shared functional common variant each region. Fine-mapping all loci will be required reveal markers that are important within populations.