Estrogen Treatment After Ovariectomy Protects Against Fatty Liver and May Improve Pathway-Selective Insulin Resistance

• DOI: 10.2337/db11-1718
• Publication Date: 2012-09-11T06:15:43Z
• Authors: Lin Zhu; William C. Brown; Qing Cai; Andrée Krust; Pierre Chambon; Owen P. McGuinness; John M. Stafford
• Keywords: Hyperinsulinemia

Pathway-selective insulin resistance where fails to suppress hepatic glucose production but promotes liver fat storage may underlie and lipid abnormalities after menopause. We tested the mechanisms by which estrogen treatment alter impact of a high-fat diet (HFD) when given at time ovariectomy (OVX) in mice. Female C57BL/6J mice underwent sham operation, OVX, or OVX with estradiol (E2) were fed an HFD. Hyperinsulinemic-euglycemic clamps used assess sensitivity, tracer incorporation into lipids, triglyceride export. had increased adiposity that was prevented E2 OVX. sensitivity In mice, HFD feeding induced fatty liver, reduced apoB100 deposition decrease export during hyperinsulinemia. lacking receptor α, limited failed improve limit deposition, prevent suppression conclusion, reverse aspects pathway-selective promoting action on metabolism limiting deposition.