Insulin Resistance Is Accompanied by Increased Fasting Glucagon and Delayed Glucagon Suppression in Individuals With Normal and Impaired Glucose Regulation

• DOI: 10.2337/db16-0240
• Publication Date: 2016-08-09T02:33:13Z
• Authors: Kristine Færch; Dorte Vistisen; Giovanni Pacini; Signe S. Torekov; Nanna B. Johansen; Daniel R. Witte; Anna Jonsson; Oluf Pedersen; Torben Hansen; Torsten Lauritzen; Marit E. Jørgensen; Bo Ahrén; Jens Juul Holst
• Keywords: Blood sugar regulation

Hyperinsulinemia is an adaptive mechanism that enables the maintenance of normoglycemia in presence insulin resistance. We assessed whether glucagon also involved adaptation to A total 1,437 individuals underwent oral glucose tolerance test with measurements circulating glucose, insulin, and concentrations at 0, 30 120 min. Early suppression was defined as period from 0 min, late min after intake. Insulin sensitivity estimated by validated index. Individuals screen-detected diabetes had 30% higher fasting levels diminished early suppression, but greater when compared normal (P ≤ 0.014). Higher resistance associated levels, less < 0.001). The relationship between nonlinear In conclusion, increased delayed together develop parallel Therefore, during may depend not only on hyperinsulinemia ability suppress