Hyperlipidemia-Induced MicroRNA-155-5p Improves β-Cell Function by TargetingMafb

• DOI: 10.2337/db17-0313
• Publication Date: 2017-10-03T00:20:13Z
• Authors: Mengyu Zhu; Yuanyuan Wei; Claudia Geißler; Kathrin Abschlag; Judit Corbalán Ca...; Michael Hristov; Julia Möllmann; Michael Lehrke; Ela Karshovska; Andreas Schober
• Keywords: Hyperlipidemia

A high-fat diet increases bacterial lipopolysaccharide (LPS) in the circulation and thereby stimulates glucagon-like peptide 1 (GLP-1)–mediated insulin secretion by upregulating interleukin-6 (IL-6). Although microRNA-155-5p (miR-155-5p), which IL-6 expression, is upregulated LPS hyperlipidemia patients with familial hypercholesterolemia less frequently develop diabetes, role of miR-155-5p islet stress response to unclear. In this study, we demonstrate that hyperlipidemia-associated endotoxemia upregulates murine pancreatic β-cells, improved glucose metabolism adaptation β-cells obesity-induced resistance. This effect because suppression v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B, promotes β-cell function through IL-6–induced GLP-1 production α-cells. Moreover, reduced levels are associated increased obesity progression, dyslipidemia, atherosclerosis hyperlipidemic Mir155 knockout mice. Hence, induction expression improves resistance represents a protective mechanism response.