1735-P: Oral Exposure to Air Pollutants Mediates Diabetes via Innate Immunity

• DOI: 10.2337/db19-1735-p
• Publication Date: 2019-06-05T01:35:22Z
• Authors: ANGELA J.T. BOSCH; THERESA V. ROHM; SHEFAA ALASFOOR; ZORA BAUMANN; CLAUDIA CAVELTI-W...
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 13. Climate action; 11. Sustainability; 3. Good health

Background: Besides classical risk factors such as sedentary lifestyle and unhealthy diet, air pollution has emerged an unexpected factor for type 2 diabetes. However, the causal mechanism remains poorly understood. Air particles are known to reach gastrointestinal tract by mucociliary clearance. Underlining clinical relevance of oral exposure, been associated with a variety diseases. Therefore, we aim study effects exposure on glucose metabolism potential immune-mediated mechanism. Research Design Method: Male C57B6/N, Rag2-/- CCR2-/- mice or diet supplemented Csfr1-inhibitor were exposed diesel exhaust (DEP; 12µg 5 days/week) PBS gavage up 6 months. Glycemia, tissue inflammation immune cells assessed. Results: Mice orally treated DEP developed impaired tolerance reduced insulin secretion, while resistance, systemic, adipose liver not induced. This effect was independent adaptive immunity mice, which devoid B T cells, also became intolerant. In contrast, intolerance did develop in Csfr1-inhibitor. Supporting causative role intestinal macrophages pollution-induced diabetes, wild had anti-inflammatory, resident lamina propria gut. Conclusion: Oral pollutants results tolerance, is mediated innate found loss Moreover, protected from Our findings provide new understanding how environmental affect metabolic health, crucial preventing worldwide disease burden Disclosure A.J.T. Bosch: None. T.V. Rohm: S. AlAsfoor: Z. Baumann: C. Cavelti-Weder: