Monocyte miRNAs Are Associated With Type 2 Diabetes

• DOI: 10.2337/db21-0704
• Publication Date: 2022-01-24T23:04:56Z
• Authors: Daniel C. Parker; Ma Wan; Kurt Lohman; Li Hou; Anh Tram Nguyen; Jingzhong Ding; Alain Bertoni; Steve Shea; Gregory L. Burke; David R. Jacobs; Wendy Post; David Corcoran; Ina Hoeschele; John S. Parks; Yongmei Liu
• Keywords: 0301 basic medicine; MicroRNAs; 03 medical and health sciences; Glucose; Diabetes Mellitus, Type 2; Gene Expression Profiling; Humans; Genetics/Genomes/Proteomics/Metabolomics; Monocytes; Epigenesis, Genetic

miRNAs are small noncoding RNAs that may contribute to common diseases through epigenetic regulation of gene expression. Little is known regarding the role in type 2 diabetes (T2D). We performed miRNA sequencing and transcriptomic profiling peripheral monocytes from longitudinal Multi-Ethnic Study Atherosclerosis (MESA) (N = 1,154). examined associations between prevalent impaired fasting glucose T2D evaluated T2D-associated effect on incident T2D. Of 774 detected miRNAs, 6 (miR-22-3p, miR-33a-5p, miR-181c-5p, miR-92b-3p, miR-222–3p, miR-944) were associated with For five six (all but miR-222-3p), our findings suggest a dose-response relationship Two (miR-92b-3p: hazard ratio [HR] 1.64, P 1.30E-03; miR-222-3p: HR 1.97, 9.10E-03) highest versus lowest tertile Most also HDL cholesterol concentrations. The genes targeted by these belong key nodes metabolism network. Higher levels expression expected increase intracellular accumulation linked an risk.