1357-P: Conflicting Significance of High BMI as a Predictor of Individual Diabetic Complications

• DOI: 10.2337/db23-1357-p
• Publication Date: 2023-06-20T05:17:21Z
• Authors: YUTA YAGUCHI; KAZUYA FUJIHARA; LAY MON KHIN; SIJIA WU; EFREM D. FERREIRA; TAKAAKI SATO; CHIKA HORIKAWA; YASUHIRO MATSUBAY...; KIMINORI KATO; HIROHITO SONE
• Keywords: 0301 basic medicine; 0302 clinical medicine

Although weight management plays a central role in diabetes treatment, the association between body and diabetic complications is not fully elucidated. Therefore, we investigated relationship BMI risk of patients with mellius (DM) using nationwide claims data. Analyzed were 91097 DM without prior treatment-requiring eye disease (TRDED), initiation dialysis (dialysis), coronary artery (CAD), cerebrovascular (CVD), heart failure (HF) or amputation (mean age 52 y, HbA1c 7.2%, median follow-up 4.5 y). Participants divided into 6 groups according to (BMI<20.0, 20.0-22.4, 22.5-24.9, 25.0-27.4, 27.5-29.0, ≥30.0). Risk was examined by Cox regression analysis. There an inverse correlation BMI; hazard ratio (HR) for ≥30.0 0.46 (0.29-0.74). U-shaped HF HRs <20.0 1.97 (1.15-3.37) 1.76 (1.27-2.45), respectively (Figure). High significantly associated higher HF, but lower risks TRDED dialysis. The inconsistent among complications, suggesting that target should be individualized complications. Disclosure Y.Yaguchi: None. H.Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kyowa Kirin Co., Ltd., Taisho Pharmaceutical Holdings Ono Eisai Takeda Ltd. K.Fujihara: L.Khin: S.Wu: E.D.Ferreira: T.Sato: C.Horikawa: Y.Matsubayashi: K.Kato: