Functional Vascular Endothelial Growth Factor −634G>C SNP Is Associated With Proliferative Diabetic Retinopathy

• DOI: 10.2337/dc06-1399
• Publication Date: 2007-01-26T20:43:19Z
• Authors: Flavia I.V. Errera; Luís Henrique Ca...; Maria Elisabeth R...; Erika Yeh; Walter Takahashi; Katia G. Santos; Katia E.P. Souto; Balduíno Tschiedel; Israel Roisenberg; Jorge Luis Gross; Maria Rita Passos...
• Keywords: Adult; Male; Vascular Endothelial Growth Factor A; 0301 basic medicine; 0303 health sciences; Diabetic Retinopathy; Blood Pressure; Middle Aged; Lipids; Polymorphism, Single Nucleotide; White People; Body Mass Index; 3. Good health; Cohort Studies; 03 medical and health sciences; 0302 clinical medicine; Diabetes Mellitus, Type 2; Risk Factors; Case-Control Studies; Surveys and Questionnaires; Humans; Female; Physical Examination; Brazil

The purpose of this study was to evaluate the effect single nucleotide polymorphism (SNP) -634G>C at 5' regulatory region vascular endothelial growth factor (VEGF) in risk proliferative diabetic retinopathy (PDR) Brazilian population European ancestry with type 2 diabetes.A case-control conducted 501 patients ancestry. Patients underwent a standardized clinical, ophthalmological, and laboratory evaluation. Of these, 167 had PDR (case patients), 334 were considered as control subjects (patients without PDR) for PDR. A reference (110 individuals ancestry) also evaluated.No evidence association between -634G>C/VEGF presence or diabetes observed (P > 0.05). However, CC homozygous SNP significantly more frequent (37 167; 22.2%) than corresponding group (40 334; 12%) accordance recessive model = 0.003). This further when creatinine, BMI, sex, duration diabetes, HDL cholesterol, systolic blood pressure taken into account (odds ratio 1.9 [95% CI 1.01-3.79], P 0.04).The allele -634C/VEGF homozygosity is an independent development