Clinical Application of 1,5-Anhydroglucitol Measurements in Patients with Hepatocyte Nuclear Factor-1α Maturity-Onset Diabetes of the Young

• DOI: 10.2337/dc07-2334
• Publication Date: 2008-06-07T00:49:14Z
• Authors: Jan Skupien; Sylwia Gorczynska...; Tomasz Klupa; Krzysztof Wanic; Eric A. Button; Jacek Sieradzki; Maciej T. Malecki
• Keywords: Glycosuria; Fructosamine

1,5-anhydroglucitol (1,5-AG) is a short-term marker of metabolic control in diabetes. Its renal loss stimulated hyperglycemic conditions by glycosuria, which results lowered plasma concentration. As low threshold for glucose has been described hepatocyte nuclear factor-1alpha (HNF-1alpha) maturity-onset diabetes the young (MODY), 1,5-AG level may be altered these patients. The purpose this study was to assess levels patients with HNF-1alpha MODY and type 2 diabetic subjects similar degree control. In addition, we aimed evaluate particle as biomarker MODY.We included 33 from Polish Nationwide Registry MODY. examined 43 47 nondiabetic subjects. concentration measured an enzymatic assay (GlycoMark). Receiver operating characteristic (ROC) curve analysis used screening MODY.The mean mutation carriers 5.9 microg/ml, it lower than that (11.0 P = 0.003) (23.9 < 0.00005). ROC revealed 85.7% sensitivity 80.0% specificity at criterion <6.5 microg/ml A1C between 6.5 9.0%.1,5-AG useful differential diagnosis specific range A1C, although requires further investigation. However, clinical use substantial limitations.