Wound Chronicity, Inpatient Care, and Chronic Kidney Disease Predispose to MRSA Infection in Diabetic Foot Ulcers

• DOI: 10.2337/dc09-0295
• Publication Date: 2009-07-09T02:28:42Z
• Authors: Christopher Yates; Kerry May; Thomas Hale; Bernard Allard; Naomi Rowlings; Amy Freeman; Jessica Harrison; Jane McCann; Paul Wraight
• Keywords: Diabetic foot ulcer; Foot (prosody)

OBJECTIVE To determine the microbiological profile of diabetes-related foot infections (DRFIs) and impact wound duration, inpatient treatment, chronic kidney disease (CKD). RESEARCH DESIGN AND METHODS Postdebridement samples were collected from individuals presenting with DRFIs 1 January 2005 to 31 December 2007. RESULTS A total 653 specimens 379 36% identifying only one isolate. Of isolates, 77% gram-positive bacteria (staphylococci 43%, streptococci 13%). Methicillin-resistant Staphylococcus aureus (MRSA) was isolated 23%; risk factors for MRSA included prolonged duration (odds ratio 2.31), management (2.19), CKD (OR 1.49). Gram-negative more prevalent (P = 0.002) < 0.001). Pseudomonal isolates common in wounds CONCLUSIONS are predominantly due aerobes but usually polymicrobial increase complexity care ulcer duration. In presence management, or CKD, empiric antibiotic cover should be considered.