Association Among Acrylamide, Blood Insulin, and Insulin Resistance in Adults

• DOI: 10.2337/dc09-0309
• Publication Date: 2009-09-04T02:03:08Z
• Authors: Chien-Yu Lin; Yu-Chuan Lin; Hsu-Ko Kuo; Juey-Jen Hwang; Jiunn-Lee Lin; Pau-Chung Chen; Lian-Yu Lin
• Keywords: Quartile; Homeostasis; Homeostatic model assessment

Exposure to acrylamide in foodstuffs and smoking has become a worldwide concern. The effect of on glucose homeostasis is not known. goal the present study was test hypothesis that trace exposure might be independently associated with both reduced blood insulin resistance.We examined 1,356 participants reliable measures Hb adducts (HbAA) glycidamide from National Health Nutrition Examination Survey, 2003-2004. Glucose assessed by measurement plasma glucose, serum insulin, model assessment resistance (HOMA-IR).In linear regression model, 1-unit increase log HbAA decrease (beta coefficient = -0.20 +/- 0.05, P 0.001) HOMA-IR -0.23 < 0.001). After concentrations were divided into quartiles fully adjusted models, level significantly decreased across (P(trend) 0.001 for both). In subgroup analysis, association levels stronger subjects who white or had ever smoked lower education BMI <25 >30 kg/m(2).Acrylamide adults. Further clinical animal studies are warranted clarify putative causal relationship.