Markers of Oxidative Damage Are Not Elevated in Otherwise Healthy Individuals With the Metabolic Syndrome

• DOI: 10.2337/dc09-2124
• Publication Date: 2010-02-26T03:18:50Z
• Authors: Raymond C.-S. Seet; Chung-Yung J. Lee; Erle C.H. Lim; Amy M.L. Quek; Shan-Hong Huang; Chin-Meng Khoo; Barry Halliwell
• Keywords: Adult; Male; Metabolic Syndrome; gamma-Glutamyltransferase; Middle Aged; 3. Good health; Cohort Studies; Oxidative Stress; Phospholipases A2; 03 medical and health sciences; C-Reactive Protein; Cross-Sectional Studies; 0302 clinical medicine; Predictive Value of Tests; Humans; Female; Lipid Peroxidation; Biomarkers; Original Research

OBJECTIVE The role of oxidative damage in the pathogenesis of metabolic syndrome is poorly understood.

RESEARCH DESIGN AND METHODS A detailed cross-sectional study was performed to assess the relationship between lipid oxidation products, γ-glutamyltransferase, high-sensitivity C-reactive protein (hs-CRP), and phospholipase activities with respect to the metabolic status in a cohort of otherwise healthy individuals.

RESULTS A total of 179 individuals (87 men and 92 women) aged 43 ± 14 years (mean ± SD) participated in this study. There were no differences in the levels of plasma F2-isoprostanes, hydroxyeicosatetraenoic acids, cholesterol oxidation products, and phospholipase activities in individuals with features of metabolic syndrome. In multivariate analyses, serum hs-CRP was a consistent independent predictor of metabolic syndrome.

CONCLUSIONS Minimal changes were observed in multiple markers of oxidative damage in a well-characterized cohort of individuals with features of metabolic syndrome.