No Protective Effect of Calcitriol on β-Cell Function in Recent-Onset Type 1 Diabetes

• DOI: 10.2337/dc10-0814
• Publication Date: 2010-08-30T17:55:49Z
• Authors: Carla Bizzarri; Dario Pitocco; Nicola Napoli; Enrico Di Stasio; Daria Maggi; Silvia Manfrini; Concetta Suraci; Maria Gisella Cav...; Marco Cappa; Giovanni Ghirlanda; Paolo Pozzilli
• Keywords: C-peptide

OBJECTIVE We investigated whether supplementation of the active form vitamin D (calcitriol) in recent-onset type 1 diabetes can protect β-cell function evaluated by C-peptide and improve glycemic control assessed A1C insulin requirement. RESEARCH DESIGN AND METHODS Thirty-four subjects (aged 11–35 years, median 18 years) with high basal >0.25 nmol/l were randomized a double-blind trial to 0.25 μg/day calcitriol or placebo followed-up for 2 years. RESULTS At 6, 12, 24 months follow-up, requirement group did not differ from group. dropped significantly (P < 0.001) but similarly both groups, no significant differences at each time point. CONCLUSIONS doses used, is ineffective protecting (including children) diagnosis.