The Triglyceride-to-HDL Cholesterol Ratio

• DOI: 10.2337/dc10-2234
• Publication Date: 2011-07-06T04:21:35Z
• Authors: Cosimo Giannini; Nicola Santoro; Sonia Caprio; Grace Kim; Derek Lartaud; Melissa Shaw; Bridget Pierpont; Ram Weiss
• Keywords: Cut-off; Homeostatic model assessment; Stepwise regression

We evaluated whether the triglyceride-to-HDL cholesterol (TG/HDL-C) ratio is associated with insulin resistance (IR) in a large multiethnic cohort of obese youths.Obese youths (1,452) had an oral glucose tolerance test and fasting lipid profile. Insulin sensitivity was estimated using whole body index (WBISI) homeostasis model assessment (HOMA)-IR evaluated, subgroup 146 youths, by hyperinsulinemic-euglycemic clamp. The divided ethnicity (612 whites, 357 Hispanics, 483 African Americans) then stratified into ethnicity-specific tertiles TG/HDL-C ratio. Differences across were association between defined multiple stepwise linear regression analysis. area under receiver operating characteristic (ROC) curve (AUC) determined to calculate cutoff identify insulin-resistant subjects ethnicity.In each ethnic group rising ratio, progressively decreased, whereas 2-h AUC-glucose increased. for 2.27, odds presenting IR, higher than cutoff, 6.023 (95% CI 2.798-12.964; P < 0.001) white girls boys, both Hispanics Americans AUC-ROCs not significant, thus allowing calculation optimal value.The IR mainly boys may be used other risk factors at increased IR-driven morbidity.