Heterogeneity of Altered Cytokine Levels Across the Clinical Spectrum of Diabetes in China

• DOI: 10.2337/dc11-0039
• Publication Date: 2011-05-27T00:47:35Z
• Authors: Yufei Xiang; Pengcheng Zhou; Xiaojue Li; Gan Huang; Zhenqi Liu; Aimin Xu; R. David Leslie; Zhiguang Zhou
• Keywords: Adult; Male; China; 571; Diabetes Mellitus, Type 1 - blood; Type 2 - blood; Type 1 - blood; Cytokines - blood; 03 medical and health sciences; 0302 clinical medicine; Asian People; Lipocalin-2; Proto-Oncogene Proteins; Diabetes Mellitus; Humans; Original Research; Glutamate Decarboxylase; Interleukin-6; Middle Aged; Lipocalins; 3. Good health; C-Reactive Protein; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Cytokines; Adiponectin - blood; Female; Adiponectin; Diabetes Mellitus, Type 2 - blood; Acute-Phase Proteins

To determine the relationship between selected cytokines and diabetes in Chinese subjects.Adult patients with recent-onset type 1 (n=53), latent autoimmune adults (LADA) (n=250), 2 (n=285) from multiple centers were compared normal subjects (n=196). We centrally tested serum GAD antibodies (GADAs), interleukin-6 (IL-6), lipocalin (LCN2), high-sensitivity C-reactive protein (hs-CRP), adiponectin.After adjustment for age, sex, BMI, all types had increased IL-6 LCN2 (P<0.01), four LADA (P<0.01). In diabetes, adiponectin but not hs-CRP was whereas Adiponectin correlated positively GADA titer negatively (P<0.01 both).In China, inflammatory markers are three major of probably different reasons, even diabetes.