Elevated Transferrin Saturation and Risk of Diabetes

• DOI: 10.2337/dc11-0416
• Publication Date: 2011-08-27T05:26:39Z
• Authors: Christina Ellervik; Thomas Mandrup-Po...; Henrik Ullits And...; Anne Tybjærg-Hansen; Merete Frandsen; Henrik Birgens; Børge G. Nordestg...
• Keywords: Transferrin saturation

We tested the hypothesis that elevated transferrin saturation is associated with an increased risk of any form diabetes, as well type 1 or 2 diabetes separately.We used two general population studies, The Copenhagen City Heart Study (CCHS, N = 9,121) and General Population (CGPS, 24,195), a 1:1 age- sex-matched population-based case-control study 6,129 patients from Steno Diabetes Centre control subjects, totaling 8,535 37,039 subjects.In combined odds ratios in those ≥50% vs. <50% were 2.1 (95% CI 1.3-3.4; P 0.003) for diabetes; 2.6 (1.2-5.6; 0.01) 1.7 (1.4-2.1; 0.001) diabetes.Elevated confers two- to threefold developing separately.