Association of Biochemical B12 Deficiency With Metformin Therapy and Vitamin B12 Supplements

• DOI: 10.2337/dc11-1582
• Publication Date: 2011-12-17T05:57:04Z
• Authors: Lael Reinstatler; Yan Ping Qi; Rebecca S. Willia...; Joshua V. Garn; Godfrey P. Oakley
• Keywords: 2. Zero hunger; 03 medical and health sciences; 0302 clinical medicine; Original Research; 3. Good health

To describe the prevalence of biochemical B(12) deficiency in adults with type 2 diabetes taking metformin compared those not and without diabetes, explore whether this relationship is modified by vitamin supplements.Analysis data on U.S. ≥50 years age (n = 1,621) or 6,867) from National Health Nutrition Examination Survey (NHANES), 1999-2006. Type was defined as clinical diagnosis after 30 initiation insulin therapy within 1 year. Those were classified according to their current use. Biochemical serum concentrations ≤148 pmol/L borderline >148 ≤221 pmol/L.Biochemical present 5.8% using 2.4% (P 0.0026) 3.3% 0.0002). Among use associated (adjusted odds ratio 2.92; 95% CI 1.26-6.78). Consumption any supplement containing a reduction among whereas consumption two-thirds diabetes.Metformin higher deficiency. The amount recommended Institute Medicine (IOM) (2.4 μg/day) available general multivitamins (6 μg) may be enough correct diabetes.