Independent Association Between Obstructive Sleep Apnea Severity and Glycated Hemoglobin in Adults Without Diabetes

• DOI: 10.2337/dc11-2538
• Publication Date: 2012-06-12T05:59:18Z
• Authors: Pascaline Priou; Marc Le Vaillant; Nicole Meslier; Sylvaine Chollet; Philippe Masson; Marie P. Humeau; Thierry Pigeanne; Acya Bizieux-Thaminy; François Goupil; Frédéric Gagnadoux
• Keywords: Glycated hemoglobin; Apnea–hypopnea index

We tested the hypothesis of an independent cross-sectional association between obstructive sleep apnea (OSA) severity and glycated hemoglobin (HbA(1c)) in adults without known diabetes.HbA(1c) was measured whole-blood samples from 2,139 patients undergoing nocturnal recording for suspected OSA. Participants with self-reported diabetes, use diabetes medication, or HbA(1c) value ≥6.5% were excluded this study. Our final sample size comprised 1,599 patients.A dose-response relationship observed apnea-hypopnea index (AHI) percentage >6.0%, ranging 10.8% AHI <5 to 34.2% ≥50. After adjustment age, sex, smoking habits, BMI, waist circumference, cardiovascular morbidity, daytime sleepiness, depression, insomnia, duration, study site, odds ratios (95% CIs) >6.0% 1 (reference), 1.40 (0.84-2.32), 1.80 (1.19-2.72), 2.02 (1.31-3.14), 2.96 (1.58-5.54) values <5, 5 <15, 15 <30, 30 <50, ≥50, respectively. Increasing hypoxemia during also independently associated >6.0%.Among increasing OSA is impaired glucose metabolism, as assessed by higher values, which may expose them risks disease.