Is Hyperglycemia a Cardiovascular Risk Factor?

• DOI: 10.2337/dc11-s207
• Publication Date: 2011-04-27T21:30:32Z
• Authors: Frank Pistrosch; Andrea Natali; Markolf Hanefeld
• Keywords: Blood Glucose; Male; Clinical Trials as Topic; Middle Aged; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Cardiovascular Diseases; Risk Factors; Hyperglycemia; Humans; Female; Diabetes and Cardiovascular Disease; Aged

Patients with diabetes show an increased vascular morbidity and mortality that reduces their life expectancy by ~5–15 years (depending on the age at diagnosis) (1). There is convincing evidence from epidemiological pathophysiological studies hyperglycemia per se largely responsible for harmful effects of disease. As recently shown clinical trials, treatment this condition may reduce cardiovascular events mortality, several therapies should be considered: initiating early individualized avoiding hypoglycemia.

As in Multiple Risk Factor Intervention Trial, any given level major risk factors, associated odds ratio 2–4 compared nondiabetic subjects (2). These results were confirmed European Prospective Investigation Cancer Nutrition (EPIC Norfolk) study (3) a recent analysis Atherosclerosis Communities (ARIC) (4).

Furthermore, published 18-year follow-up Finland demonstrated similar impact type 1 2 mortality. The adjusted hazard ratios age-matched without 5.2 4.9 diabetes, respectively (5).

Thus, today exists long-term population-based patients diabetes. This clearly suggests key factor not only diabetes-related disease, but also all-cause On basis these observations, one can assume increment disease increase unit (%) A1C ~18% (6).

As numerous prospective studies, deleterious dysglycemia (fasting postprandial hyperglycemia) develop before diagnosed. In Glucose Tolerance Acute Myocardial Infarction acute coronary syndrome, abnormal glucose tolerance was strongest independent …