Effect of Intensive Multifactorial Treatment Compared With Routine Care on Aortic Stiffness and Central Blood Pressure Among Individuals With Screen-Detected Type 2 Diabetes

• DOI: 10.2337/dc12-0176
• Publication Date: 2012-07-12T04:54:09Z
• Authors: Nanna B. Johansen; Morten Charles; Dorte Vistisen; Signe S. Rasmussen; Niels Wiinberg; Knut Borch-Johnsen; Torsten Lauritzen; Annelli Sandbæk; Daniel R. Witte
• Keywords: Interquartile range; Pulse pressure; Aortic pressure

Diabetes is associated with increased brachial and central blood pressure aortic stiffness. We examined the effect of intensive multifactorial treatment in general practice on indices peripheral hemodynamics among patients screen-detected diabetes.As part a population-based screening intervention study practice, 1,533 Danes aged 40-69 years were clinically diagnosed diabetes. General practitioners randomized to provide or routine care. After mean follow-up 6.2 years, an unselected subsample 456 underwent hemodynamic assessments by applanation tonometry. Central was derived from radial pulse wave. Aortic stiffness assessed as carotid-femoral wave velocity (aPWV). The each index analyzed mixed-effects models adjusted for heart rate, cluster randomization, age, sex.At screening, median age 59.2 (interquartile range 55.2-64.6); 289 (63%) group, 278 (61%) men. Patients group had 0.51 m/s (95% CI -0.96 -0.05, P = 0.03) lower aPWV compared Respective differences augmentation (-0.84% [-2.54 0.86]), (0.28 mmHg [-1.75 2.32]), systolic (-1.42 [-4.47 1.64]) diastolic (-1.79 [-3.72 0.14]) not statistically significant.Intensive diabetes during 6 has significant impact stiffness, whereas effects other measures are smaller significant.