Branched-Chain and Aromatic Amino Acids Are Predictors of Insulin Resistance in Young Adults

• DOI: 10.2337/dc12-0895
• Publication Date: 2012-11-06T06:32:13Z
• Authors: Peter Würtz; Pasi Soininen; Antti J. Kangas; Tapani Rönnemaa; Terho Lehtimäki; Mika Kähönen; Jorma S. Viikari; Olli T. Raitakari; Mika Ala-Korpela
• Keywords: Isoleucine

Branched-chain and aromatic amino acids are associated with the risk for future type 2 diabetes; however, underlying mechanisms remain elusive. We tested whether predict insulin resistance index in healthy young adults.Circulating isoleucine, leucine, valine, phenylalanine, tyrosine, six additional were quantified 1,680 individuals from population-based Cardiovascular Risk Young Finns Study (baseline age 32 ± 5 years; 54% women). Insulin was estimated by homeostasis model assessment (HOMA) at baseline 6-year follow-up. Amino acid associations HOMA of (HOMA-IR) glucose assessed using regression models adjusted established factors. further examined profiling could augment (defined as HOMA-IR >90th percentile) early adulthood.Isoleucine, tyrosine men follow-up, while women only phenylalanine predicted (P < 0.05). None other prospectively HOMA-IR. The sum branched-chain concentrations (odds ratio 2.09 [95% CI 1.38-3.17]; P = 0.0005); including score prediction did not improve discrimination.Branched-chain markers development young, normoglycemic adults, most pronounced men. These findings suggest that association diabetes is least partly mediated through resistance.