Parenteral Nutrition–Associated Hyperglycemia in Non–Critically Ill Inpatients Increases the Risk of In-Hospital Mortality (Multicenter Study)

• DOI: 10.2337/dc12-1379
• Publication Date: 2012-12-07T05:07:50Z
• Authors: Gabriel Olveira; María José Tapia; Julia Ocón; Carmen Cabrejas-G...; María D. Balleste...; Alfonso Vidal-Cas...; Carmen Arraiza-Ir...; Josefina Olivares; Maria del Carmen ...; Álvaro García-Man...; Francisco Botella...; Rosa P. Quílez-To...; Lucio Cabrerizo; Pilar Matia; Luisa Chicharro; Rosa Burgos; Pedro Pujante; Mercedes Ferrer; Ana Zugasti; Javier Prieto; Marta Diéguez; María José Carrera; Anna Vila-Bundo; Juan Ramón Urgelés; Carmen Aragón-Valera; Adela Rovira; Irene Bretón; Pilar García-Peris; Araceli Muñoz-Garach; Efren Márquez; Dolores del Olmo; José Luis Pereira; María C. Tous
• Keywords: Male; Critical Illness; Middle Aged; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Hyperglycemia; Humans; Female; Parenteral Nutrition, Total; Hospital Mortality; Prospective Studies; Original Research; Aged

Hyperglycemia may increase mortality in patients who receive total parenteral nutrition (TPN). However, this has not been well studied noncritically ill (i.e., the nonintensive care unit setting). The aim of study was to determine whether mean blood glucose level during TPN infusion is associated with increased hospitalized patients.This prospective multicenter involved 19 Spanish hospitals. Noncritically were prescribed included prospectively, and data collected on demographic, clinical, laboratory variables as in-hospital mortality.The 605 (mean age 63.2 ± 15.7 years). daily values 1.630 323 kcal, 3.2 0.7 g carbohydrates/kg, 1.26 0.3 amino acids/kg, 0.9 0.2 lipids/kg. Multiple logistic regression analysis showed that had levels >180 mg/dL a risk 5.6 times greater than those <140 (95% CI 1.47-21.4 mg/dL) after adjusting for age, sex, nutritional state, presence diabetes or hyperglycemia before starting TPN, diagnosis, prior comorbidity, carbohydrates infused, use steroid therapy, SD level, insulin units supplied, infectious complications, albumin, C-reactive protein, HbA1c levels.Hyperglycemia higher mortality.