One-Hour Glucose During an Oral Glucose Challenge Prospectively Predicts β-Cell Deterioration and Prediabetes in Obese Hispanic Youth

• DOI: 10.2337/dc12-1861
• Publication Date: 2013-01-12T06:48:56Z
• Authors: Joon Young Kim; Michael I. Goran; Claudia M. Toledo...; Marc J. Weigensberg; Myunghan Choi; Gabriel Q. Shaibi
• Keywords: Prediabetes; Impaired fasting glucose; Glucose tolerance test

In adults, 1-h glucose during an oral tolerance test (OGTT) predicts the development of type 2 diabetes independent fasting and 2-h concentrations. The purpose current investigation was to examine utility elevated levels prospectively predict deterioration in β-cell function prediabetes high-risk youth.Obese Latino youth with a family history (133 male 100 female; age 11.1 ± 1.7 years) completed baseline OGTT were divided into two groups based upon threshold 155 mg/dL (<155 mg/dL, n = 151, or ≥ 82). Youth followed annually for up 8 years assessment tolerance, body composition by dual-energy X-ray absorptiometry, insulin sensitivity, secretion, disposition index frequently sampled intravenous test.Over time, group exhibited significantly greater decline compared <155 (β -327.8 126.2, P 0.01). Moreover, this composition. When data restricted only participants normal at baseline, independently associated 2.5 times likelihood developing follow-up (95% CI 1.6-4.1, 0.0001).These suggest that is predictor progression among obese youth.