Sex-Specific Association of Fetuin-A With Type 2 Diabetes in Older Community-Dwelling Adults

• DOI: 10.2337/dc12-1870
• Publication Date: 2013-01-12T06:48:56Z
• Authors: Gail A. Laughlin; Elizabeth Barrett...; Kevin M. Cummins; Lori B. Daniels; Christina L. Wassel; Joachim H. Ix
• Keywords: Adult; Male; alpha-2-HS-Glycoprotein; Incidence; Middle Aged; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Diabetes Mellitus, Type 2; Glucose Intolerance; Prevalence; Humans; Female; Original Research; Aged

This study evaluated the sex-specific association of plasma fetuin-A levels with prevalent and incident type 2 diabetes in community-dwelling older adults.Participants were 684 men 1,058 women (median age, 71 years) whose levels, prevalence, risk factors 1992-1996. The participants followed for through 2010 follow-up, 9 years).Women impaired glucose tolerance had elevated compared normal (P = 0.019), but not fasting glucose. Fetuin-A did vary by status men. There significant interactions sex 0.007) 0.020) diabetes. For women, each SD (0.10 g/L) higher level was associated a odds (odds ratio [OR] 1.79, 95% CI 1.47-2.17) greater (hazard [HR] 1.66, 1.18-2.34), adjusting age estrogen therapy. These associations materially altered adjustment attenuated postchallenge levels. Among men, although positive (OR 1.15 [0.94-1.41]) (HR 1.24 [0.93-1.65]) suggested age-adjusted models, estimates to one after multivariable adjustment.Higher concentrations independently an increased developing related may provide novel insights into mechanisms underlying differences homeostasis old age.