Changes in Insulin Resistance and HbA1c Are Related to Exercise-Mediated Changes in Body Composition in Older Adults With Type 2 Diabetes

• DOI: 10.2337/dc12-2196
• Publication Date: 2013-03-09T05:21:42Z
• Authors: Yorgi Mavros; Shelley Kay; Kylie A. Anderberg; Michael K. Baker; Yi Wang; Renru Zhao; Jacinda Meiklejohn; Mike Climstein; Anthony O’Sullivan; Nathan de Vos; Bernhard T. Baune; Steven N. Blair; David Simar; Kieron Rooney; Nalin Singh; Maria A. Fiataron...
• Keywords: Bioelectrical Impedance Analysis; Homeostatic model assessment; Homeostasis; GLUT4

To investigate changes in body composition after 12 months of high-intensity progressive resistance training (PRT) relation to insulin (IR) or glucose homeostasis older adults with type 2 diabetes.One-hundred three participants were randomized receive either PRT sham exercise 3 days per week for months. Homeostasis model assessment (HOMA2-IR) and glycosylated hemoglobin (HbA1c) used as indices IR homeostasis. Skeletal muscle mass (SkMM) total fat assessed using bioelectrical impedance. Visceral adipose tissue, mid-thigh cross-sectional area, attenuation quantified computed tomography.Within the group, HOMA2-IR associated SkMM (r = -0.38; P 0.04) 0.42; 0.02). Changes visceral tissue tended be related 0.35; 0.07). HbA1c 0.52; 0.001). None these relationships present group (P > 0.05). Using ANCOVA models, who had increased decreased 0.05) 0.09) compared those lost SkMM. Increases 0.07) < group.Improvements metabolic health diabetes mediated through improvements only if they achieved PRT.