Obesity as a Mediator of the Influence of Cardiorespiratory Fitness on Cardiometabolic Risk: A Mediation Analysis

• DOI: 10.2337/dc13-0416
• Publication Date: 2013-11-07T03:13:01Z
• Authors: Ana Díez-Fernández; Mairena Sánchez-L...; Ricardo Mora-Rodr...; Blanca Notario-Pa...; Coral Torrijos-Niño; Vicente Martínez-...
• Keywords: Male; Metabolic Syndrome; 2. Zero hunger; Heart; 16. Peace & justice; Body Mass Index; 3. Good health; 03 medical and health sciences; Cross-Sectional Studies; 0302 clinical medicine; Cardiovascular Diseases; Physical Fitness; Risk Factors; Spain; Exercise Test; Respiratory Physiological Phenomena; Humans; Female; Obesity; Child

The relationship between cardiorespiratory fitness (CRF) and metabolic syndrome (MetS) is well known, although the extent to which body weight may act as a confounder or mediator in this uncertain. aim of study was examine whether association CRF cardiometabolic risk factors mediated by BMI.A cross-sectional including 1,158 schoolchildren aged 8-11 years from province Cuenca, Spain, undertaken. We measured height, weight, waist circumference (WC), blood pressure, fasting plasma lipid profile insulin, (20-m shuttle run test). A validated index estimated summing standardized z scores WC, log triglyceride-to-HDL cholesterol ratio (TG/HDL-c), mean arterial pressure (MAP), insulin. To assess BMI, linear regression models were fitted according Baron Kenny procedures for mediation analysis.In girls, BMI acts full factors, with exception TG/HDL-c ratio. In boys, both MAP, partial factors.BMI mediates MetS schoolchildren. Overall, good levels are associated lower risk, particularly when accompanied reduction.