Brachial-Ankle Pulse Wave Velocity Predicts All-Cause Mortality and Cardiovascular Events in Patients With Diabetes: The Kyushu Prevention Study of Atherosclerosis

• DOI: 10.2337/dc13-1886
• Publication Date: 2014-06-05T03:58:29Z
• Authors: Yasutaka Maeda; Toyoshi Inoguchi; Erina Etoh; Yoshimi Kodama; Shuji Sasaki; Noriyuki Sonoda; Hajime Nawata; Michio Shimabukuro; Ryoichi Takayanagi
• Keywords: Male; Incidence; Middle Aged; Pulse Wave Analysis; Atherosclerosis; Prognosis; 3. Good health; Cohort Studies; 03 medical and health sciences; Vascular Stiffness; 0302 clinical medicine; Japan; Predictive Value of Tests; Cause of Death; Hypertension; Humans; Ankle Brachial Index; Female; Diabetic Angiopathies; Aged; Proportional Hazards Models

Whether brachial-ankle pulse wave velocity (baPWV), a noninvasive marker for arterial stiffness, is useful predictive maker cardiovascular events in subjects with diabetes not established. In the present cohort study, we evaluated benefit of baPWV prediction morbidity and mortality diabetes.A total 4,272 outpatients were enrolled Kyushu Prevention Study Atherosclerosis. Of these, 3,628 subjects, excluding those an ankle-brachial index <0.9, prospectively followed 3.2 ± 2.2 years. The at baseline was classified by recursive partitioning (RP) each end point. We plotted Kaplan-Meier curves high- low-baPWV groups, which designated based on cutoff points, calculated Cox proportional hazards models.The elevation quartiles significantly correlated to incidence coronary artery events, cerebrovascular all-cause mortality. RP revealed baPWVs 14 24 m/s as statistically adequate points mortality, respectively. High-baPWV classes showed low event-free ratios all remained independent risks but after adjustments age, sex, BMI, hypertension, hyperlipidemia, smoking, hemoglobin A1c models.This large-scale study provided evidence that high predictor diabetes.