A1C Combined With Glycated Albumin Improves Detection of Prediabetes in Africans: The Africans in America Study

• DOI: 10.2337/dc15-1699
• Publication Date: 2016-01-07T20:06:19Z
• Authors: Anne E. Sumner; Michelle T. Duong; Paola C. Aldana; Madia Ricks; Marshall K. Tullo...; Jay N. Lozier; Stephanie T. Chung; David B. Sacks
• Keywords: Fructosamine; Prediabetes; Glycated hemoglobin

OBJECTIVE Slowing the diabetes epidemic in Africa requires improved detection of prediabetes. A1C, a form glycated hemoglobin A, is recommended for diagnosing The proteins, fructosamine and albumin (GA), are hemoglobin-independent alternatives to but their efficacy Africans unknown. Our goals were determine ability fructosamine, GA detect prediabetes U.S.-based value combining A1C with either or GA. RESEARCH DESIGN AND METHODS Oral glucose tolerance tests (OGTT) performed 217 self-identified healthy African immigrants (69% male, age 39 ± 10 years [mean SD], BMI 27.6 4.5 kg/m2). measured. Prediabetes was diagnosed by American Diabetes Association criteria obtained from 2-h OGTT. thresholds diagnose cutoff at upper tertile each variable: ≥5.7% (39 mmol/mol) (range 4.2–6.6% [22.4–48.6 mmol/mol]), ≥230 µmol/L 161–269 µmol/L), ≥13.35% 10.20–16.07%), respectively. RESULTS occurred 34% (74 217). diagnostic sensitivities 50%, 41%, 42%, P values comparison both >0.3. Combining increased sensitivities. However, sensitivity combined not better than alone (72% vs. = 0.172). In contrast, higher (78% < 0.001). CONCLUSIONS As individual tests, detected ≤50% made it possible identify nearly 80%