Nondiabetic Glucometabolic Status and Progression of Aortic Stiffness: The Whitehall II Study

• DOI: 10.2337/dc16-1773
• Publication Date: 2017-01-26T02:25:33Z
• Authors: Carmel M. McEniery; Ian B. Wilkinson; Nanna B. Johansen; Daniel R. Witte; Archana Singh-Manoux; Mika Kivimaki; Adam G. Tabak; Eric J. Brunner; Martin J. Shipley
• Keywords: Adult; Blood Glucose; Male; cardiovascular risk factors; Cardiovascular and Metabolic Risk; Glycated Hemoglobin A; pulse wave velocity; Observational Study; Pulse Wave Analysis; glucometabolic status; 03 medical and health sciences; Vascular Stiffness; 0302 clinical medicine; Research Support, N.I.H., Extramural; Metabolic Diseases; Risk Factors; Journal Article; Diabetes Mellitus; Humans; Longitudinal Studies; Prospective Studies; Glycated Hemoglobin; Research Support, Non-U.S. Gov't; Middle Aged; 3. Good health; aortic stiffening; Cross-Sectional Studies; Cardiovascular Diseases; Disease Progression; Female; Insulin Resistance; Follow-Up Studies

OBJECTIVE Aortic stiffness is an important predictor of future morbidity and mortality. Diabetes associated with increased aortic stiffness, but the importance nondiabetic glucometabolic status for accelerated stiffening unclear. We tested hypothesis that adverse in individuals without diabetes, independently known risk factors arterial stiffening. RESEARCH DESIGN AND METHODS Glucometabolic other cardiovascular were assessed at baseline 2008–09, carotid femoral pulse wave velocity (cfPWV) follow-up 2012–13, 4,386 participants diabetes Whitehall II Study. RESULTS The mean age cohort cfPWV was 60 years, 74% male. from (mean ± SE) 8.30 0.03 to 8.98 0.04 m/s during 4 years follow-up. At baseline, fasting 2-h postload glucose, HbA1c, HOMA-insulin resistance (HOMA-IR). HbA1c HOMA-IR progression after adjusting physiological confounders factors. A 1 SD higher greater increases (0.11 per 5 [95% CI 0.04, 0.18], P = 0.003 0.09 [0.01, 0.17], 0.03, respectively). Additional adjustment BMI weakened association not HbA1c. CONCLUSIONS diabetes. These findings suggest long-term status, even could be target preventative strategies against vascular aging.