Impaired Sensitivity to Thyroid Hormones Is Associated With Diabetes and Metabolic Syndrome

• DOI: 10.2337/dc18-1410
• Publication Date: 2018-12-15T01:09:58Z
• Authors: Martin Laclaustra; Belen Moreno-Franco; Jose Manuel Lou-B...; Rocio Mateo-Gallego; Jose Antonio Casa...; Pilar Guallar-Cas...; Ana Cenarro; Fernando Civeira
• Keywords: Thyroid-stimulating hormone; Quartile

OBJECTIVE Diabetes prevalence and incidence increase among individuals with hypothyroidism but also those hyperthyroxinemia, which seems contradictory. Both high free thyroxine (fT4) thyroid-stimulating hormone (TSH) are present in the resistance to thyroid syndrome. A mild acquired might occur general population be associated diabetes. We aimed analyze association of indices (the Thyroid Feedback Quantile-based Index [TFQI], proposed this work, previously used Thyrotroph T4 Resistance TSH Index) RESEARCH DESIGN AND METHODS calculated aforementioned based on a U.S. representative sample 5,129 ≥20 years age participating 2007–2008 National Health Nutrition Examination Survey (NHANES). Also, approximate TFQI, U.S.-referenced Parametric TFQI (PTFQI) can spreadsheet formula =NORM.DIST(fT4_cell_in_pmol_per_L,10.075,2.155,TRUE)+NORM.DIST(LN(TSH_cell_in_mIU_per_L),0.4654,0.7744,TRUE)−1. Outcomes interest were glycohemoglobin ≥6.5%, diabetes medication, diabetes-related deaths (diabetes as contributing cause death), additionally, fasting subsample, metabolic Logistic Poisson regressions adjusted for sex, age, race/ethnicity. RESULTS Odd ratios fourth versus first quartile 1.73 (95% CI 1.32, 2.27) (Ptrend = 0.002) positive 1.66 1.31, 2.10) 0.001) medication. Diabetes-related death rate ratio being above below median was 4.81 1.01, 22.94) 0.015). Further adjustment BMI restriction normothyroid yielded similar results. Per 1 SD odds increased 1.13 1.02, 1.25) 1.16 1.31) The other showed associations CONCLUSIONS Higher values obesity, syndrome, diabetes, mortality. may reflect energy balance problems driving type 2 These facilitate monitoring treatments focused balance.