Microvascular Disease in Patients With Diabetes With Heart Failure and Reduced Ejection Versus Preserved Ejection Fraction

• DOI: 10.2337/dc18-2515
• Publication Date: 2019-07-10T20:05:15Z
• Authors: Jasper Tromp; Shir Lynn Lim; Wan Ting Tay; Tiew-Hwa Katherin...; Chanchal Chandram...; Wouter Ouwerkerk; Gupreet S. Wander; Jitendra P.S. Saw...; Jonathan Yap; Michael R. MacDonald; Lieng Hsi Ling; Naveed Sattar; John J.V. McMurray; A. Mark Richards; Inder Anand; Carolyn S.P. Lam; ; Mark Richards; Carolyn S.P. Lam; Inder Anand; Chung-Lieh Hung; Lieng His Ling; Houng Bang Liew; Calambur Narasimhan; Tachapong Ngarmukos; Sang Weon Park; Eugenio Reyes; Bambang B. Siswanto; Wataru Shimizu; Shu Zhang
• Keywords: Male; Diabetic Cardiomyopathies; 610; RECOMMENDATIONS; 03 medical and health sciences; 0302 clinical medicine; Cause of Death; Prevalence; Humans; COHORT; Prospective Studies; Registries; POPULATION; CITY CARDIOMYOPATHY QUESTIONNAIRE; Aged; Proportional Hazards Models; RISK; Heart Failure; COMPLICATIONS; Stroke Volume; ADULTS; Middle Aged; Prognosis; 16. Peace & justice; ASIANS; PREVALENCE; 3. Good health; Microvessels; Quality of Life; Female; SUDDEN CARDIAC DEATH; Diabetic Angiopathies

Microvascular complications are common among patients with diabetes mellitus (DM). The presence of heart failure (HF) is presumed to be due macrovascular disease (typically HF reduced ejection fraction [HFrEF] following myocardial infarction). We hypothesized that preserved (HFpEF) in DM may a manifestation microvascular compared HFrEF. objective this study was examine the prevalence and association clinical outcome DM.We investigated prevalence, outcome, cardiac structure function (neuropathy, nephropathy, retinopathy) 2,800 prospectively enrolled participants (561 HFpEF) from Asian Sudden Cardiac Death In Heart Failure (ASIAN-HF) registry.A total 601 (21.5%) had complications. Participants any (one or more) were more likely have HFpEF (odds ratio 1.70 [95% CI 1.15-2.50]; P = 0.008). Furthermore, likelihood having increased an increasing number (Ptrend < 0.001). associated left ventricular (LV) hypertrophy greater reduction quality life than HFrEF (Pinteraction 0.001 for all). Compared without complications, adjusted hazard composite all-cause death hospitalization 1.35 (95% 1.04-1.76) regardless type 0.112).Diabetic common, related LV remodeling, impairment life, similar adverse outcomes, DM.