Preoperative Circulating Succinate Levels as a Biomarker for Diabetes Remission After Bariatric Surgery

• DOI: 10.2337/dc19-0114
• Publication Date: 2019-08-03T02:39:04Z
• Authors: Victoria Ceperuel...; Gemma Llauradó; Noelia Keiran; Ester Benaiges; Brenno Astiarraga; Laia Martínez; Silvia Pellitero; Jose Miguel Gonzá...; Amaia Rodríguez; José Manuel Ferná...; Albert Lecube; Ana Megía; Nuria Vilarrasa; Joan Vendrell; Sonia Fernández-V...
• Keywords: Sleeve gastrectomy

OBJECTIVE To determine the potential use of baseline circulating succinate to predict type 2 diabetes remission after bariatric surgery. RESEARCH DESIGN AND METHODS Forty-five obese patients with were randomly assigned Roux-en-Y gastric bypass (RYGB), sleeve gastrectomy (SG), or laparoscopic greater curvature plication. Anthropometric parameters evaluated, and a complete biochemical analysis including serum concentrations was performed at 1 year The results externally validated in second cohort 88 RYGB SG based on clinical criteria. RESULTS Succinate an independent predictor Patients achieving had lower levels (47.8 [37.6–64.6] µmol/L vs. 64.1 [52.5–82.9] µmol/L; P = 0.018). Moreover, significantly decreased surgery (58.9 [46.4–82.4] 46.0 [35.8–65.3] µmol/L, 0.005). In multivariate analysis, best logistic regression model showed that (odds ratio [OR] 11.3, 0.031) (OR 26.4, 0.010) independently associated remission. C-statistic for this 0.899 (95% CI 0.809–0.989) derivation cohort, which improved prediction compared current available scores, 0.729 0.612–0.846) validation cohort. Interestingly, different response according succinate, significant differences rates. CONCLUSIONS Circulating is reduced Baseline have predictive value previously described presurgical factors improve upon scores