Association of Maternal Prepregnancy Diabetes and Gestational Diabetes Mellitus With Congenital Anomalies of the Newborn

• DOI: 10.2337/dc20-0261
• Publication Date: 2020-10-22T00:35:19Z
• Authors: Yuxiao Wu; Buyun Liu; Yangbo Sun; Yang Du; Mark K. Santillan; Donna A. Santillan; Linda G. Snetselaar; Wei Bao
• Keywords: Adult; Male; Adolescent; Pregnancy Rate; Infant, Newborn; Pregnancy in Diabetics; Middle Aged; Congenital Abnormalities; 3. Good health; Diabetes, Gestational; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Pregnancy; Risk Factors; Humans; Female

OBJECTIVE To examine the association of maternal prepregnancy diabetes, gestational diabetes mellitus (GDM), and 12 subtypes congenital anomalies newborn. RESEARCH DESIGN AND METHODS We included 29,211,974 live births with age ranging from 18 to 49 years old documented in National Vital Statistics System U.S. 2011 2018. Information on GDM, was retrieved birth certificates. Log-binomial regression used estimate risk ratios (RRs) 95% CIs for overall by subtypes. RESULTS Of births, there were 90,061 infants who had identified at birth. The adjusted RRs 2.44 (95% CI 2.33–2.55) 1.28 1.24–1.31) GDM. associations generally consistent across subgroups age, race/ethnicity, obesity status, infant sex. For specific anomalies, or GDM associated an increased most example, cyanotic heart disease 4.61 4.28–4.96) 1.50 1.43–1.58) GDM; hypospadias 1.88 1.67–2.12) 1.29 1.21–1.36) CONCLUSIONS Prepregnancy and, a lesser extent, several These findings suggest potential benefits preconception counseling women preexisting prevention anomalies.