Longitudinal Association of Depressive Symptoms, Binge Eating, and Quality of Life With Cardiovascular Risk Factors in Young Adults With Youth-Onset Type 2 Diabetes: The TODAY2 Study

• DOI: 10.2337/dc21-1995
• Publication Date: 2022-03-15T16:28:36Z
• Authors: Marsha D. Marcus; Rachelle Gandica; Laure El ghormli; Janine Higgins; Bereket Tesfaldet; Dorit Koren; Sarah Macleish; Elia Nila Escaname; Ruth S. Weinstock
• Keywords: Depression; Longitudinal Study

OBJECTIVE To report the prevalence of depression, eating disorder symptoms, and impaired health-related quality life (HRQOL) examine their longitudinal associations with glycemia diabetes complications in young adults youth-onset type 2 diabetes. RESEARCH DESIGN AND METHODS Participants recruited over a 4-year period were enrolled at 15 clinical centers follow-up observational Treatment Options for Type Diabetes Adolescents Youth (TODAY2) study. From 2014–2020, symptoms disorders, HRQOL by sex, race/ethnicity, baseline family income assessed annually. Longitudinal relationships between assessments psychiatric evaluated adjusted models. RESULTS (n = 514) 21.7 ± 2.5 years old duration 8.6 1.5 year 1 TODAY (2014). Symptoms depression common increased significantly 6 (14.0% to 19.2%, P 0.003; 13.1% 16.7%, 0.009, respectively). Depression more women those lower but did not differ race/ethnicity. Rates binge stable time; self-reported purging increased. Over time, associated higher HbA1c, hypertension, retinopathy progression; was BMI, systolic blood pressure, disorders BMI. CONCLUSIONS Significant are among emerging positively glycemia, progression this group that is ongoing risk medical morbidity.