Urinary Zinc and Incident Type 2 Diabetes: Prospective Evidence From the Strong Heart Study

• DOI: 10.2337/dc22-1152
• Publication Date: 2022-09-22T12:09:49Z
• Authors: Marta Galvez-Fern...; Martha Powers; Maria Grau-Perez; Arce Domingo-Relloso; Nancy Lolacono; Walter Goessler; Ying Zhang; Amanda Fretts; Jason G. Umans; Nisa Maruthur; Ana Navas-Acien
• Keywords: Prediabetes

OBJECTIVE Hyperglycemia can increase urinary zinc excretion. We evaluated the association of higher level with new diagnosis incident type 2 diabetes mellitus (T2DM) in adult populations a high burden T2DM from AZ, OK, and ND SD. also assessed cross-sectional levels prevalent prediabetes. RESEARCH DESIGN AND METHODS included 1,339 adults free at baseline (1989–1991) followed through 1998–1999 Strong Heart Study (SHS) 1,905 family members SHS participants as part Family (SHFS) 2006–2009. RESULTS incidence was 14.7% (mean follow-up 6.6 years) 13.5% 5.6 SHFS. After adjustment for sex, site, education, smoking status, BMI, estimated glomerular filtration rate, hazard ratio comparing 75th vs. 25th percentiles distribution 1.21 (95% CI 1.08, 1.36) 1.12 (0.96, 1.31) These associations were attenuated but significant after HOMA insulin resistance (HOMA-IR) score. With exclusion prediabetes baseline, remained significantly associated SHS. In analyses, levels. CONCLUSIONS Urinary prevalence even HOMA-IR T2DM. results highlight importance metabolism development.