Impact of Overnight Glucose on Next-Day Functioning in Adults With Type 1 Diabetes: An Exploratory Intensive Longitudinal Study

• DOI: 10.2337/dc22-2008
• Publication Date: 2023-03-02T20:30:46Z
• Authors: Elizabeth A. Pyatak; Donna Spruijt-Metz; Stefan Schneider; Raymond Hernandez; Loree T. Pham; Claire J. Hoogend...; Anne L. Peters; Jill Crandall; Haomiao Jin; Pey-Jiuan Lee; Jeffrey S. Gonzalez
• Keywords: Moderation

OBJECTIVE While there is evidence that functioning, or ability to perform daily life activities, can be adversely influenced by type 1 diabetes, the impact of acute fluctuations in glucose levels on functioning poorly understood. RESEARCH DESIGN AND METHODS Using dynamic structural equation modeling, we examined whether overnight (coefficient variation[CV], percent time <70 mg/dL, >250 mg/dL) predicted seven next-day outcomes (mobile cognitive tasks, accelerometry-derived physical activity, self-reported activity participation) adults with diabetes. We mediation, moderation, and short-term relationships were predictive global patient-reported outcomes. RESULTS Overall was significantly from CV (P = 0.017) mg/dL 0.037). Pairwise tests indicate higher associated poorer sustained attention 0.028) lower engagement demanding activities 0.028), 0.007), more sedentary 0.024). The partially mediated sleep fragmentation. Individual differences effect predict illness intrusiveness 0.016) diabetes-related quality 0.036). CONCLUSIONS Overnight predicts problems objective These findings across diverse highlight wide-ranging effects