Long-Term Exposure to Fine Particulate Matter and Fasting Blood Glucose and Diabetes in 20 Million Chinese Women of Reproductive Age

• DOI: 10.2337/dc23-2153
• Publication Date: 2024-05-22T19:10:54Z
• Authors: Yang Shen; Lifang Jiang; Xiaoxu Xie; Xia Meng; Xianrong Xu; Jing Dong; Ying Yang; Jihong Xu; Ya Zhang; Qiaomei Wang; Haiping Shen; Yiping Zhang; Donghai Yan; Lu Zhou; Yixuan Jiang; Renjie Chen; Haidong Kan; Jing Cai; Yuan He; Xu Ma
• Keywords: Interquartile range; Attributable risk

OBJECTIVE Evidence of the associations between fine particulate matter (PM2.5) and diabetes risk from women reproductive age, in whom may have adverse long-term health effects for both themselves future generations, remains scarce. We therefore examined PM2.5 exposure with fasting blood glucose (FBG) level age China. RESEARCH DESIGN AND METHODS This study included 20,076,032 20–49 years participating National Free Preconception Health Examination Project China 2010 2015. was estimated using a satellite-based model. Multivariate linear logistic regression models were used to examine FBG risk, respectively. Diabetes burden attributable fraction (AF) number. RESULTS showed monotonic relationships elevated risk. Each interquartile range (27 μg/m3) increase 3-year average concentration associated 0.078 mmol/L (95% CI 0.077, 0.079) 18% 16%, 19%) higher diabetes. The AF attributed exceeding 5 μg/m3 29.0% 27.5%, 30.5%), corresponding an additional 78.6 thousand 74.5, 82.6) cases. Subgroup analyses more pronounced risks those who overweight or obese, >35 years, less educated, minority ethnicity, registered as rural household, residing western CONCLUSIONS found