Hyperglycemia-Induced Thrombin Formation in Diabetes: The Possible Role of Oxidative Stress

• DOI: 10.2337/diab.44.8.924
• Publication Date: 2013-09-19T17:22:06Z
• Authors: Antonio Ceriello; Roberta Giacomello; Giuliana Stel; Enrico Motz; Claudio Taboga; Laura Tonutti; Mario Pirisi; Edmondo Falleti; Ettore Bartoli
• Keywords: Blood Glucose; Male; Thrombin; Glucose Tolerance Test; Glutathione; 3. Good health; Cohort Studies; Oxidative Stress; 03 medical and health sciences; 0302 clinical medicine; Diabetes Mellitus, Type 2; Reference Values; Hyperglycemia; Humans; Female; Aged

Diabetes is characterized by the existence of a thrombosis-prone condition, possibly related to hyperglycemia. However, mechanism linking hyperglycemia activation coagulation cascade still unclear. It has been recently suggested that diabetes accompanied increased oxidative stress. In this work, possibility stress may be involved in hyperglycemia-induced evaluated. Prothrombin fragment 1 + 2 (F1+2), which represents reliable marker amount thrombin released circulation, chosen for studying formation vivo. nine type II diabetic patients and seven healthy control subjects, matched age body mass index, three different experiments were performed: oral glucose tolerance test (OGTT), intravenous antioxidant glutathione (GSH) administration h, OGTT plus GSH administration. Samples drawn at −15 min every 30 from 0 180 min. During OGTT, F1+2 significantly both subjects. during normalized phenomenon. administered alone decreased patients, while no effect was observed normal These data suggest induce activation, inducing an stress, counterbalance effect.