Visceral Fat and Race-Dependent Health Risks in Obese Nondiabetic Premenopausal Women

• DOI: 10.2337/diab.46.3.456
• Publication Date: 2013-09-19T17:42:54Z
• Authors: Jeanine B Albu; Laura Murphy; David H Frager; Julia A Johnson; F Xavier Pi-Sunyer
• Keywords: Body Fat Percentage; Waist–hip ratio; Intra-Abdominal Fat

Our previous finding that a waist-to-hip ratio (WHR) >0.85 was not associated with similar health risks in black, compared white, obese premenopausal nondiabetic women of fatness is attributed to either 1) different relationship between WHR and visceral adiposity or 2) differences the metabolic abnormalities obesity. We measured (VAT) subcutaneous adipose tissue (SCAT) areas at midwaist 25 black white BMI, percentage body fat, wide range (0.7–0.95 for 0.7–0.9 women) then insulin sensitivity index (SI), glucose under 2-h curve (AUCs) during an oral tolerance test (OGTT), blood lipids two groups before after adjustments total adiposity. After adjusting fat mass (FM), had significantly less VAT (by 32 cm2) lower VAT/SCAT any given WHR. The regression equations predicting SI, AUCs, triglyceride HDL cholesterol levels from regional measurements (VAT, SCAT, VAT/SCAT) (FM fat) slopes were women. LDL independently related but SI AUC, AUC higher (P < 0.001), FM. Regression analysis pooled data showed high VAT/SCAT, predicted AUCs OGTT, levels, independent conclude while increases adversely affect metabolism both women, are risk factors these groups.