Promoter Polymorphisms of the TNF-α (G-308A) and IL-6 (C-174G) Genes Predict the Conversion From Impaired Glucose Tolerance to Type 2 Diabetes

• DOI: 10.2337/diabetes.52.7.1872
• Publication Date: 2007-03-06T19:04:22Z
• Authors: Agata Kubaszek; Jussi Pihlajamäki; Vladislav Komarovski; Virpi Lindi; Jaana Lindström; Johan Eriksson; Timo T. Valle; Helena Hämäläinen; Pirjo Ilanne-Parikka; Sirkka Keinänen-...; Jaakko Tuomilehto; Matti Uusitupa; Markku Laakso
• Keywords: Analysis of Variance; 0303 health sciences; Time Factors; Genotype; Interleukin-6; Tumor Necrosis Factor-alpha; Body Weight; Mutation, Missense; Polymorphism, Single Nucleotide; 3. Good health; 03 medical and health sciences; Diabetes Mellitus, Type 2; Reference Values; Risk Factors; Glucose Intolerance; Disease Progression; Humans; Promoter Regions, Genetic

High levels of cytokines are risk factors for type 2 diabetes. Therefore, we investigated whether the promoter polymorphisms tumor necrosis factor-alpha (TNF-alpha; G-308A) and interleukin 6 (IL-6; C-174G) genes predict conversion from impaired glucose tolerance (IGT) to diabetes in Finnish Diabetes Prevention Study. Altogether, 490 overweight subjects with IGT whose DNA was available were randomly divided into one two treatment assignments: control group intensive, individualized diet exercise intervention group. The -308A allele TNF-alpha gene associated an approximate twofold higher compared G-308G genotype (odds ratio 1.80, 95% CI 1.05-3.09; P = 0.034). Subjects both A C-174C IL-6 had a 2.2-fold (CI 1.02-4.85, 0.045) developing than without genotypes. We conclude that polymorphism (G-308A) is predictor Furthermore, this seems have gene-gene interaction gene.