Serum Ferritin as a Component of the Insulin Resistance Syndrome

• DOI: 10.2337/diacare.21.1.62
• Publication Date: 2007-03-05T22:51:27Z
• Authors: José-Manuel Ferná...; Wifredo Ricart-Engel; Enric Arroyo; Rafael Balançá; Roser Casamitjana...; Dolores Cabrero; Miquel Fernández-...; Joan Soler
• Keywords: Component (thermodynamics)

OBJECTIVE In epidemiological studies, serum ferritin was the second-strongest determinant of blood glucose (after BMI) in regression models and third-strongest insulin BMI age). Its concentration also correlated positively with plasma triglycerides apolipoprotein B concentrations, negatively HDL2 cholesterol. We hypothesized that could be a marker resistance. RESEARCH DESIGN AND METHODS Oral tolerance sensitivity (SI, minimal model method) were prospectively evaluated 36 healthy subjects. The relationship between metabolic control (as measured by HbA1c levels) studied 76 consecutive NIDDM patients. RESULTS subjects, log-transformed (LOGFER) basal (r = 0.44, P 0.007), but not BMI, age, systolic or diastolic pressure, total cholesterol, VLDL HDL triglycerides, insulin, (all NS). Identical results obtained when two lowest quartiles separately. However, highest quartiles, LOGFER (0.50, 0.02), pressure 0.8, < 0.0001), LDL cholesterol 0.57, 0.01), 0.48, 0.03), HDL3 subtractions −0.68, −0.76, −0.55, 0.001. 0.0001, 0.01, respectively), 0.60, 0.006), HDL2/HDL3 quotient (P −0.71, 0.001), 0.65, 0.004), uric acid 0.51, 0.38, 0.15). After adjusting for only correlations 0.7, 0.002) −0.63, 0.01) remained significant. Strong area under curve during oral test (Pearson's r 0.73, 0.001) S1 which significant after controlling observed. (β −0.44, −0.52, 0.004) constituted independent predictors multivariate analysis (R2 0.68). outpatients, 0.00001) 0.03) independently predicted value 0.40) multiple linear analysis. CONCLUSIONS among quotient, curve, suggest resistance syndrome. Serum may an poor diabetic patient.