Five-Week, Low–Glycemic Index Diet Decreases Total Fat Mass and Improves Plasma Lipid Profile in Moderately Overweight Nondiabetic Men

• DOI: 10.2337/diacare.25.5.822
• Publication Date: 2007-03-05T22:51:27Z
• Authors: Clara Bouché; Salwa W. Rizkalla; Jing Luo; Hubert Vidal; Annie Veronese; Nathalie Pacher; Caroline Fouquet; Vincent Lang; Gérard Slama
• Keywords: Adult; Blood Glucose; Leptin; Male; 0301 basic medicine; 2. Zero hunger; Cross-Over Studies; Time Factors; Body Weight; Receptors, Cytoplasmic and Nuclear; Middle Aged; Lipids; Lipoprotein Lipase Activators; 3. Good health; 03 medical and health sciences; Humans; Insulin; Obesity; RNA, Messenger; Peptides; Transcription Factors

OBJECTIVE—To evaluate whether a 5-week low–glycemic index (LGI) diet versus high–glycemic (HGI) can modify glucose and lipid metabolism as well total fat mass in nondiabetic men. RESEARCH DESIGN AND METHODS—In this study, 11 healthy men were randomly allocated to 5 weeks of an LGI or HGI separated by washout interval crossover design. RESULTS—The resulted lower postprandial plasma insulin profiles areas under the curve (AUCs) than diet. A period lowered triacylglycerol excursion after lunch (AUC, P < 0.05 vs. HGI). These modifications associated with decrease ∼700 g (P 0.05) tendency increase lean body 0.07) without any change weight. This was accompanied leptin, lipoprotein lipase, hormone-sensitive lipase RNAm quantities subcutaneous abdominal adipose tissue 0.05). CONCLUSIONS—We concluded that ameliorates some parameters, decreases mass, tends changing changes expression genes implicated metabolism. Such could be benefit healthy, slightly overweight subjects might play role prevention metabolic diseases their cardiovascular complications.