Radial Artery Tonometry Demonstrates Arterial Stiffness in Children With Type 1 Diabetes

• DOI: 10.2337/diacare.27.12.2911
• Publication Date: 2007-03-05T22:51:27Z
• Authors: Michael J. Haller; Margaret Samyn; Wilmer W. Nichols; Todd Brusko; Clive Wasserfall; R. Fletcher Schwartz; Mark Atkinson; Jonathan J. Shuster; Gary L. Pierce; Janet H. Silverstein
• Keywords: Male; Peripheral Vascular Diseases; Adolescent; Manometry; Body Mass Index; 3. Good health; 03 medical and health sciences; Diabetes Mellitus, Type 1; 0302 clinical medicine; Reference Values; Radial Artery; Humans; Female; Child; Diabetic Angiopathies

OBJECTIVE—To determine if children with type 1 diabetes have increased arterial stiffness by estimating augmentation index the simple noninvasive technique of radial artery tonometry. RESEARCH DESIGN AND METHODS—We studied 98 diabetic and 57 healthy control subjects, ages 10–18 years, matched for age, sex, race, BMI, generating 43 pairs. Radial tonometry was performed, blood collected analysis fasting lipids, HbA1c, glucose, cytokines in all children. RESULTS—Children had a significantly higher corrected to heart rate 75 (AI75) than their subjects. Mean AI75 subjects 1.11 ± 10.15 versus −3.32 10.36 The case-control difference 5.20 11.02 (P = 0.0031). CONCLUSIONS—Children compared is that could be added armamentarium tests used provide cardiovascular risk stratification diabetes.