Metabolic Syndrome

• DOI: 10.2337/diacare.29.01.06.dc05-1320
• Publication Date: 2006-04-22T05:21:16Z
• Authors: Lynn E. Eberly; Ronald Prineas; Jerome D. Cohen; Gabriela Vazquez; Xin Zhi; James D. Neaton; Lewis H. Kuller
• Keywords: 03 medical and health sciences; 0302 clinical medicine

OBJECTIVE—To examine the long-term association of metabolic syndrome with mortality among those at high risk for cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS—A total 10,950 Multiple Risk Factor Intervention Trial (MRFIT) survivors were followed an additional median 18.4 years (1980–1999). Proportional hazards models examined multivariate-adjusted risks associated Adult Treatment Panel III–defined conditions, BMI substituted waist circumference. RESULTS—At MRFIT annual visit 6, 4,588 (41.9%) men, mean age (±SD) 53.0 ± 5.9 years, had and 6,362 did not. Comparing men to without, adjusted hazard ratios (HRs) 1.21 (95% CI 1.13–1.29), 1.49 (1.35–1.64), 1.51 (1.34–1.70) 18-year total, CVD, coronary heart mortality, respectively. Among syndrome, elevated glucose (1.54 [1.34–1.78]) low HDL cholesterol (1.45 [1.17–1.54]) most predictive CVD by (1.34 [1.17–1.54]), blood pressure (1.25 [0.98–1.58]), triglycerides (1.06 [0.86–1.30]). In contrast, without HR was 1.02 (0.86–1.22). no nonfatal event, smokers LDL showed higher (1.79 [1.22–2.63]) compared nonsmokers cholesterol; this even greater a event (2.11 [1.32–3.38]). CONCLUSIONS—Metabolic is increased mortality. further having more cigarette smoking, cholesterol. Primary prevention each condition should be emphasized, presence treated in accordance current guidelines.