Profibrotic circulating proteins and risk of early progressive renal decline in Type 2 Diabetes patients with and without albuminuria

• DOI: 10.2337/figshare.12808433.v1
• Publication Date: 2020-09-04T18:49:24Z
• Authors: Katsuhito Ihara; Jan Skupien; Hiroki Kobayashi; Zaipul I. Md Dom; Jonathan M. Wilson; Kristina O’Neil; Hannah S. Badger; Lenden M. Bowsman; Eiichiro Satake; Matthew D. Breyer; Kevin L. Duffin; Andrzej S. Krolewski
• Keywords: Albuminuria; Quartile

<b>OBJECTIVE</b>: The role of fibrosis in early progressive renal decline type 2 diabetes is unknown. Circulating WFDC2 (WAP four-disulfide core domain protein 2) and MMP-7 (Matrilysin) are postulated to be biomarkers fibrosis. This study examined an association circulating levels these proteins with decline. <p><b>RESEARCH DESIGN AND METHODS</b>: Individuals enrolled the Joslin Kidney Study eGFR ≥60 ml/min/1.73m<sup>2</sup> were followed for 6-12 years ascertain fast defined as loss ≥5 ml/min/1.73m<sup>2</sup>/year. </p> <p><b>RESULTS</b>: A total 1,181 individuals studied: 681 without 500 albuminuria. Median ACR at baseline 97 24 mg/g, respectively. During follow-up, 152 experienced decline: 6.9% those normoalbuminuria 21% In both subgroups risk increased increasing (p <0.0001) <0.0001). After adjustment relevant clinical characteristics known biomarkers, increase by one quartile Fibrosis Index (combination MMP-7) was associated higher (OR 1.63; 95% CI 1.30-2.04). similar statistically significant among patients <p><b>CONCLUSIONS: </b>Elevation profibrotic development diabetes. independent from albuminuria status points importance fibrotic process