<strong>Intramyocellular Triglyceride Content During the Early Course of Type 1 and Type 2 Diabetes Mellitus</strong>

• DOI: 10.2337/figshare.23710308.v1
• Publication Date: 2023-07-21T17:40:07Z
• Authors: Martin Schön; Oana P. Zaharia; Klaus Strassburger; Yuliya Kupriyanova; Kálmán Bódis; Geronimo Heilmann; Alexander Strom; Gidon J. Bönhof; Filippo Michelotti; Iryna Yurchenko; Clara Möser; Maximilian Huttasch; Maria Bombrich; Malte Kelm; Volker Burkart; Vera B. Schrauwen...; Robert Wagner; Michael Roden; the GDS group
• Keywords: Microalbuminuria

&lt;p&gt;Intramyocellular lipid content (IMCL) is elevated in insulin-resistant humans, but its changes over time and relationships with comorbidities remain unclear. We examined IMCL during the initial course of diabetes associations complications. Participants German Diabetes Study (GDS) recent-onset type 1 (n=132) or 2 (n=139) glucose-tolerant controls (n=128) underwent 1H-magnetic resonance spectroscopy to measure muscle volume, whole-body insulin sensitivity (hyperinsulinemic-euglycemic clamps; M-value) cycling spiroergometry (VO2max). Subgroups same measurements after 5 years. At baseline, was ~30% higher than other groups independently age, sex, BMI volume. In diabetes, M-value ~36% ~62% lower compared controls, respectively. After years, decreased by ~29% ~13% whereas remained unchanged. The correlation at baseline modulated VO2max. also associated microalbuminuria, Framingham risk score for cardiovascular disease cardiac autonomic neuropathy. Changes within years diagnosis do not mirror progression resistance associate early diabetes-related complications.&lt;/p&gt;